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Small children with obstructive snooze apnea who are handled with codeine for post-tonsillectomy and/or adenoidectomy pain may be notably delicate to its respiratory depressant effect; thanks to hazard of daily life-threatening respiratory despair and death: codeine is contraindicated in all kids more youthful than 12 years of age; It is additionally contraindicated for put up-operative administration in pediatric clients younger than 18 a long time of age adhering to tonsillectomy and/or adenoidectomy
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fentanyl intranasal and codeine each enhance sedation. Avoid or Use Alternate here Drug. Restrict use to people for whom different treatment choices are inadequate
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abiraterone improves amounts of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Keep an eye on. Stay away from coadministration of abiraterone with substrates of CYP2D6. If different therapy cannot be used, exercise warning and look at a dose reduction on the CYP2D6 substrate.
dacomitinib will raise the amount or result of codeine by impacting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Prevent use with CYP2D6 substrates where small will increase in focus from the CYP2D6 substrate may perhaps bring about major or daily life-threatening toxicities.
Existence-threatening respiratory depression and Dying have happened in young children read more who been given codeine; codeine is issue to variability in metabolism dependent upon CYP2D6 genotype; primarily based upon post-advertising and marketing studies, kids < twelve yrs look like far more vulnerable to respiratory depressant results of codeine, particularly if there are hazard components for respiratory depression; scenarios of Loss of life have been documented in the put up-operative period read more of time following tonsillectomy and/or adenoidectomy, and several of the children had evidence of currently being ultra-quick metabolizers of codeine
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